PubMed

[Gene therapy]  
2005 Feb - Hinyokika kiyo. Acta urologica Japonica
Gotoh A, Shirakawa T, Wada Y, Hinata N, Terao S, Hara I, Arakawa S, Kamidono S, Okada H, Takenaka A, Fujisawa M
The International Center for Medical Research, Kobe University School of Medicine.
We look forward to evolution in this field to provide an established treatment for recurrent prostate cancer and are committed to actively continuing with the development of gene therapy through translational research.

[Gene therapy]  
2005 Feb - Hinyokika kiyo. Acta urologica Japonica
Gotoh A, Shirakawa T, Wada Y, Hinata N, Terao S, Hara I, Arakawa S, Kamidono S, Okada H, Takenaka A, Fujisawa M
The International Center for Medical Research, Kobe University School of Medicine.
We selected bone-metastatic prostate cancer as the target form of recurrent prostate cancer and developed a suicide-gene therapy based on an adenovirus vector with an organ-specific osteocalcin promoter. Related clinical studies have already been conducted in the United States at the University...

Immunotherapy and gene therapy.  
2004 Feb - IDrugs : the investigational drugs journal
Simpson E
Imperial College, MRC Clinical Sciences Centre, Hammersmith Hospital, London, W12 ONN, UK. elizabeth.simpson@csc.mrc.ac.uk
The Immunotherapy and Gene Therapy meeting of the Academy of Medical Sciences reviewed the state-of-the-art and translational prospects for therapeutic interventions aimed at killing tumor cells, correcting genetic defects and developing vaccines for chronic infections. Crucial basic science...

Viral gene therapy.  
2006 Dec - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Mancheño-Corvo P, Martín-Duque P
Dpto. de Biotecnología. Universidad Francisco de Vitoria. Pozuelo de Alarcón, Madrid. Spain.
... vectors derived from retroviruses, adenovirus, adeno-associated virus, herpesvirus and poxvirus are employed in more than 70% of clinical gene therapy trials worldwide. Because these vector systems have unique advantages and limitations, each has applications for which it is best suited. Retroviral...

[Gene therapy: what is it and what is its use?]  
2005 Jan-Mar - Anales del sistema sanitario de Navarra
Ruiz Castellanos M, Sangro B
Unidad de Hepatología, Clínica Universitaria de Navarra.
Gene therapy has developed as a method of approach to the treatment of human diseases based on the transfer of genetic material to the cells of an individual. Normally, the aim of this transfer of genetic material is to re-establish a cellular function that has been abolished or is defective,...

Gene therapy and the skin.  
2004 Nov 15 - American journal of medical genetics. Part C, Seminars in medical genetics
Hengge UR, Bardenheuer W
Department of Dermatology, University of Düsseldorf, Germany. ulrich.hengge@uni-duesseldorf.de
Significant progress has been made during the past decade in corrective gene therapy of the skin. This includes advances in vector technology, targeted gene expression, gene replacement, gene correction, and the availability of appropriate animal models for a variety of candidate diseases....

[Gene therapy of pain]  
- Casopís lékar̆ů c̆eských
Rokyta R
Ustav normální, patologické a klinické fyziologie 3. LF UK, Praha. richard.rokyta@lf3.cuni.cz
From all these results it is possible to conclude, that gene therapy will be definitely used for the treatment of pain and that only the intensive research in this field may bring some important results.

[Gene therapy of pain]  
- Casopís lékar̆ů c̆eských
Rokyta R
Ustav normální, patologické a klinické fyziologie 3. LF UK, Praha. richard.rokyta@lf3.cuni.cz
Possible practical applications of gene therapy for pain are at the beginning. Very intensive research on animal models has been effectuated and some partial results of clinical applications in men already exist. The article describes different possibilities of these applications, namely...

Non-viral and viral vectors for gene therapy.  
2005 Sep 02 - Cellular and molecular biology (Noisy-le-Grand, France)
Boulaiz H, Marchal JA, Prados J, Melguizo C, Aránega A
Department of Morphological Sciences, University of Granada, School of Medicine, E-18012 Granada, Spain. hboulaiz@ugr.es
Human gene therapy can be defined as the delivery of genetic material into a patient's cells with a therapeutic aim. The success or failure of gene therapy depends on the development and efficiency of the transfection of viral and non-viral vectors. Viral vectors typically offer higher...

[Prospects of gene therapy]  
- Wiadomości lekarskie (Warsaw, Poland : 1960)
Barańska M, Skretkowicz J
Z Zakładu Farmakogenetyki Uniwersytetu Medycznego w Lodzi.
In recent years extensive development of gene therapy strategies has been observed. The studies on gene therapy focus on two different research methods. The first one concerns replacement of damaged genes in somatic cells of the organism by correcting genes. Application of modem methods...

Principles of gene therapy.  
2007 Oct-Dec - Indian journal of dental research : official publication of Indian Society for Dental Research
Mammen B, Ramakrishnan T, Sudhakar U,
Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, India. mammen_biju@yahoo.co.in
... encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is designed to introduce genetic material into cells to compensate for abnormal genes or to make a beneficial protein. This article reviews the fundamentals in gene therapy and its...

[Recent developments in gene therapy]  
- Verhandelingen - Koninklijke Academie voor Geneeskunde van België
Vandendriessche T
Centrum voor Transgene Technologie en Gentherapie, Vlaams Interuniversitair Instituut voor Biotechnologie, KU Leuven--Campus Gasthuisberg--N & O, Herestraat 49-B 3000 Leuven.
Gene therapy is defined as the introduction of genetic material in a patient's cells with resulting therapeutic benefit. It is a promising new biomedical discipline that could potentially lead to new treatments for hereditary diseases, cardiovascular and neurologic disorders, cancer, diabetes...

Gene therapy in clinical medicine.  
2004 Oct - Postgraduate medical journal
Selkirk SM
Department of Neurology, University Hospital of Cleveland, Hanna House 5, 11100 Euclid Avenue, Cleveland, OH 44106, USA. stephen_selkirk@hotmail.com
Although the field of gene therapy has experienced significant setbacks and limited success, it is one of the most promising and active research fields in medicine. Interest in this therapeutic modality is based on the potential for treatment and cure of some of the most malignant and...

Switching on the lights for gene therapy.  
2007 Jun 13 - PLoS ONE
Winkeler A, Sena-Esteves M, Paulis LE, Li H, Waerzeggers Y, Rückriem B, Himmelreich U, Klein M, Monfared P, Rueger MA, Heneka M, Vollmar S, Hoehn M, Fraefel C, Graf R, Wienhard K, Heiss WD, Jacobs AH
Laboratory for Gene Therapy and Molecular Imaging at the Max Planck-Institute for Neurological Research, Center for Molecular Medicine (CMMC) and Department of Neurology, University of Cologne, Cologne, Germany.
... Non-invasive assessment of the dynamics of gene regulation is of interest for the detection of endogenous disease-specific biological alterations (e.g., signal transduction) and for monitoring the induction and regulation of therapeutic genes (e.g., gene therapy). To demonstrate that non-invasive...

Gene therapy: future or flop.  
2006 Aug - Pediatric clinics of North America
Park F, Gow KW
Department of Medicine, Kidney Disease Center, Medical College of Wisconsin, 8701 Watertown Plank Rd., HRC 4100, Milwaukee, WI 53226, USA. fpark@mcw.edu
Many pediatric diseases have now reached a therapeutic plateau using standard therapy. Gene therapy has emerged as an exciting new means to achieve specific therapeutic benefit. Although there have been important and promising breakthroughs in recent clinical trials, there have been some...

Gene Therapy for {beta}-Thalassemia.  
- Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
Malik P, Arumugam PI
Gene transfer for beta-thalassemia requires gene transfer into hematopoietic stem cells using integrating vectors that direct regulated expression of beta globin at therapeutic levels. Among integrating vectors, oncoretroviral vectors carrying the human beta-globin gene and portions of...

Viral gene therapy.  
2006 Dec - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Mancheño-Corvo P, Martín-Duque P
Dpto. de Biotecnología. Universidad Francisco de Vitoria. Pozuelo de Alarcón, Madrid. Spain.
Cancer is a multigenic disorder involving mutations of both tumor suppressor genes and oncogenes. A large body of preclinical data, however, has suggested that cancer growth can be arrested or reversed by treatment with gene transfer vectors that carry a single growth inhibitory or pro-apoptotic...

Non-invasive Imaging in Gene Therapy.  
2007 Sep - Molecular therapy : the journal of the American Society of Gene Therapy
Räty JK, Liimatainen T, Unelma Kaikkonen M, Gröhn O, Airenne KJ, Jumani Airenne K, Ylä-Herttuala S
Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.
Several methods are available for non-invasive imaging of gene delivery and transgene expression, including magnetic resonance imaging (MRI), single photon emission tomography (SPECT)/positron emission tomography (PET), and fluorescence and bioluminescence imaging. However, these imaging...

Gene therapy and wound healing.  
2007 Jan-Feb - Clinics in dermatology
Eming SA, Krieg T, Davidson JM
Department of Dermatology, University of Cologne, D-50937 Cologne, Germany.
Wound repair involves the sequential interaction of various cell types, extracellular matrix molecules, and soluble mediators. During the past 10 years, much new information on signals controlling wound cell behavior has emerged. This knowledge has led to a number of novel therapeutic...

Gene doping.  
- Essays in biochemistry
Harridge SD, Velloso CP
Division of Applied Biomedical Research, School of Biomedical and Health Sciences, 4.14 Shepherd's House Guy's Campus, King's College London, London SE1 1UL, UK. s.harridge@kcl.ac.uk
Gene doping is the misuse of gene therapy to enhance athletic performance. It has recently been recognised as a potential threat and subsequently been prohibited by the World Anti-Doping Agency. Despite concerns with safety and efficacy of gene therapy, the technology is progressing steadily....