PubMed

Linear system analysis of ion channel modulation in ro  
- Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
Liu XD, Kourennyi DE
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
... response than the inactivation gate. Linearization of ion channels for small perturbations provides an attractive alternative method to quantitatively evaluate the physiological significance of the effects of the modulation of ion channels. The resultant linear system may help reveal important...

Oxygen sensing by ion channels.  
- Essays in biochemistry
Kemp PJ, Peers C
Cardiff School of Bioscience, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK. kemp@cf.ac.uk
... have evolved which can sense and rapidly respond to an acute reduction in oxygen and central to this ability in many is dynamic modulation of ion channels by hypoxia. The most widely studied oxygen-sensitive ion channels are potassium channels but oxygen sensing by members of both the...

Ion channels as potential targets for the treatment of d  
2008 Sep - Current opinion in drug discovery & development
Lodge NJ, Li YW
Bristol-Myers Squibb, Neuroscience Biology, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. Nicholas.Lodge@bms.com
... depressive disorder is highly prevalent and remains inadequately treated. Numerous studies have demonstrated that modulation of ion channel activity can reduce depression-like behavior in animal models or depressive symptoms in humans. N-Methyl-D-aspartate and nicotinic acetylcholine receptor...

1alpha,25(OH)2 Vitamin D3 actions on ion channels i  
2006 Apr - Steroids
Zanello LP, Norman A
Department of Biochemistry, University of California, Riverside, 92521, USA. laura.zanello@ucr.edu
Membrane-initiated cellular responses to steroids include modulation of ion channel activities via signal transduction pathways. However, the molecular mechanisms involved in nongenomic actions remain only partially understood. Our research has focused on the rapid effects of 1alpha,25(OH)(2)...

Regulation of neuronal ion channels via P2Y receptor  
2004 Dec - Purinergic signalling
Lechner SG, Boehm S
Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.
... -aspartate, vanilloid, and P2X receptors, and the regulating entities include most of the known P2Y receptor subtypes. The functional consequences of the modulation of ion channels by nucleotides acting at pre- or postsynaptic P2Y receptors are changes in the strength of synaptic transmission.

High throughput assay technologies for ion channel dr  
2004 Oct - Assay and drug development technologies
Zheng W, Spencer RH, Kiss L
Department of Automated Biotechnology, Merck Research Laboratories, West Point, PA 19486, USA.
... channels have emerged as attractive drug targets. Several existing medications elicit their therapeutic effect through the modulation of ion channels, underscoring the importance of ion channels as a target class for modern drug discovery. To meet the increasing demand for high-throughput...

Hexagonal, square, and stripe patterns of the ion cha  
2007 Jan - Physical review. E, Statistical, nonlinear, and soft matter physics
Hilt M, Zimmermann W
Theoretische Physik, Universität Bayreuth, D-95440 Bayreuth, Germany.
... finite wave number are favored at the onset of pattern formation, whereby the wave number decreases with the kinetic rate of the binding-release reaction. In a two-dimensional extended membrane hexagonal modulations of the ion channel density are preferred in a large range of parameters.

Modulation of potassium channels as a therapeutic ap  
- Current pharmaceutical design
Lawson K, McKay NG
Biomedical Research Centre, Sheffield Hallam University, Faculty of Health and Wellbeing, City Campus, Sheffield, S1 1WB, UK. K.Lawson@shu.ac.uk
... the clinical setting has been limited. Tissue delivery of genes, in combination with drugs, may be an avenue enabling specific modulation of ion channel function and improved drug selectivity. Using specific examples (HERG, IKs, KCNQs, KCa, Kv1.3), issues regarding distribution, function...

Allosteric modulation of ligand-gated ion channels.  
2005 Nov 1 - Biochemical pharmacology
Hogg RC, Buisson B, Bertrand D
Department of Neurosciences, Medical Faculty, CMU 1, rue Michel Servet, CH-1211 Geneva 4, Switzerland. Ronald.Hogg@medecine.unige.ch
Ligand-gated ion channels (LGICs) are cell surface proteins that play an important role in fast synaptic transmission and in the modulation of cellular activity. Due to their intrinsic properties, LGICs respond to neurotransmitters and other effectors (e.g. pH) and transduce the binding...

Proton modulation of ion channels in isolated horizont  
2007 Jun 1 - The Journal of physiology
Jonz MG, Barnes S
Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5 Canada. mjonz@uottawa.ca
... extracellular pH (pH(o)) occur in the retina and may have profound effects on neurotransmission and visual processing due to the pH sensitivity of ion channels. The present study characterized the effects of acidification on the activity of membrane ion channels in isolated horizontal cells (HCs)...

Endogenous regulator of G-protein signaling proteins  
2006 Apr - Molecular pharmacology
Clark MA, Lambert NA
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-2300, USA.
Slow synaptic potentials are generated when metabotropic G-protein-coupled receptors activate heterotrimeric G-proteins, which in turn modulate ion channels. Many neurons generate excitatory postsynaptic potentials mediated by G-proteins of the Galphaq/11 family, which in turn activate...

Pharmacological modulation of ion channels and trans  
2004 Jun - Cell calcium
Ravens U, Wettwer E, Hála O
Department of Pharmacology and Pharmacotherapy, Medical University of Szeged, Dóm Tér 12, H-6701 Szeged, Hungary.
Ion channels and transporter proteins are prerequisites for formation and conduction of cardiac electrical impulses. Acting in concert, these proteins maintain cellular Na(+) and Ca(2+) homeostasis. Since intracellular Ca(2+) concentration determines contractile activation, we expect the...

Tethering naturally occurring peptide toxins for cell-au  
2004 Aug 5 - Neuron
Ibañez-Tallon I, Wen H, Miwa JM, Xing J, Tekinay AB, Ono F, Brehm P, Heintz N
Howard Hughes Medical Institute, Laboratory of Molecular Biology, The Rockefeller University, New York, NY 10021, USA.
The physiologies of cells depend on electrochemical signals carried by ion channels and receptors. Venomous animals produce an enormous variety of peptide toxins with high affinity for specific ion channels and receptors. The mammalian prototoxin lynx1 shares with alpha-bungarotoxin the...

Chirality in anesthesia II: stereoselective modulation o  
2006 Jul - Anesthesia and analgesia
Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA.
... movement in 50% of animals and one (2-hexanol) that was not to frog oocytes. Each oocyte expressed one of three anesthetic-sensitive ion channels: a Twik-related-spinal cord K+ (TRESK) channel, a gamma-amino butyric acid type A (GABA(A)) receptor and an N-methyl-d-aspartate (NMDA) receptor. Using...

Modulation of plant ion channels by oxidizing and red  
2005 Feb 1 - Archives of biochemistry and biophysics
Scholz-Starke J, Gambale F, Carpaneto A
Istituto di Biofisica, Genova, C.N.R., Via De Marini 6, 16149 Genova, Italy.
Ion channels are proteins forming hydrophilic pathways through the membranes of all living organisms. They play important roles in the electrogenic transport of ions and metabolites. Because of biophysical properties such as high selectivity for the permeant ion, high turnover rate, and...

Modulation of acid-sensing ion channel activity by nitri  
2007 Nov 28 - The Journal of neuroscience : the official journal of the Society for Neuroscience
Cadiou H, Studer M, Jones NG, Smith ES, Ballard A, McMahon SB, McNaughton PA
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
Acid-sensing ion channels (ASICs) are a class of ion channels activated by extracellular protons and are believed to mediate the pain caused by tissue acidosis. Although ASICs have been widely studied, little is known about their regulation by inflammatory mediators. Here, we provide evidence...

Activation and modulation of ligand-gated ion channel  
- Physiological research / Academia Scientiarum Bohemoslovaca
Krůsek J, Dittert I, Hendrych T, Hník P, Horák M, Petrovic M, Sedlácek M, Susánková K, Svobodová L, Tousová K, Ujec E, Vlachová V, Vyklický L, Vyskocil F, Vyklický L
Departent of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
... acetylcholine, glutamate and vanilloid receptors during their activation, inactivation and desensitization. Distinct families of ion channels were selected to illustrate a rich complexity of the functional states and conformational transitions these proteins undergo. Particular attention...

Bending of z-lines by mechanical stimuli: an input sign  
2008 Jun-Jul - Progress in biophysics and molecular biology
Dyachenko V, Christ A, Gubanov R, Isenberg G
Department of Physiology, Martin-Luther-University Halle, Halle, Germany.
We studied which components of mechanical cell deformation are involved in "stretch modulated ion currents" (SMIC). Murine ventricular myocytes were attached to glass coverslips and deformed in x, y and z with a 16 microm thin glass stylus (S) of calibrated stiffness. Three-dimensional...

Allosteric modulation of ion channels: the case of max  
2004 Apr 6 - Science's STKE : signal transduction knowledge environment
Rothberg BS
Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229, USA. rothberg@uthscsa.edu
... gating is modulated by both membrane voltage and cytoplasmic Ca2+. Recent work has led to a quantitative understanding of this dual regulatory mechanism, derived from classical allosteric principles, in terms of the energetic coupling among membrane voltage, Ca2+ binding, and opening of the...

Modulation of ion channels in pulmonary arterial hyper  
- Current pharmaceutical design
Guibert C, Marthan R, Savineau JP
Université Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, Bordeaux, France.
Pulmonary arterial hypertension (PAH) is a disease characterized by a progressive increase in pulmonary arterial pressure leading to right ventricular hypertrophy, right heart failure and ultimately to death. PAH is a disease of small pulmonary arteries inducing vascular narrowing leading...